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This Month in The Journal.

Auer et al., page 794 Exome sequencing in small cohorts has been successfully employed for the discovery of rare, highly penetrant mutations in familial diseases. However, the use of exome sequencing for identifying low-frequency variants in large populations has been confounded by technical limitations and prohibitive costs. To apply low-frequency variants captured by exome sequencing to a lar...

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This Month in Anesthesiology

Most previous studies comparing lung isolation methods and devices have been performed by anesthesiologists who had extensive experience in thoracic anesthesia. With the increasing demand for one-lung ventilation, it is also important to define which device can be used most effectively by occasional users. In this issue, Campos et al. report on a study comparing the success rates of three diffe...

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This Month in Anesthesiology

To further explore controversies surrounding parental presence and children’s anxiety during anesthesia induction, Caldwell-Andrews et al. devised and tested a measure to examine parents’ motivation to be present during the induction process: Motivation for Parental Presence during Induction of Anesthesia (MPPIA). The team then used the newly created measure to determine if the level of parent ...

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This Month in Anesthesiology

To address debates over recommended perioperative fluid management, Nisanevich et al. designed a randomized prospective study to compare liberal versus restricted fluid administration during intraabdominal surgery. The team enrolled 152 patients scheduled to undergo intraabdominal surgery, and randomly assigned half of them (n 75) to receive liberal amounts of lactated Ringer’s solution (bolus ...

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ژورنال

عنوان ژورنال: American Journal of Human Genetics

سال: 2021

ISSN: ['0002-9297', '1537-6605']

DOI: https://doi.org/10.1016/j.ajhg.2021.05.006